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KMID : 1025520150570010046
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Journal of Animal Science and Technology
2015 Volume.57 No. 1 p.46 ~ p.46
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Innate immunity and carbohydrate metabolism alterations precede occurrence of subclinical mastitis in transition dairy cows
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Dervishi Elda
Zhang Guanshi
Hailemariam Dagnachew
Dunn Suzana M.
Ametaj Burim N.
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Abstract
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Background: This study examined whether activation of innate immunity and alterations of carbohydrate and lipid metabolism precede development of subclinical mastitis (SCM).
Methods: Blood samples were collected from the coccygeal vein from 100 Holstein dairy cows at -8, -4, disease diagnosis week, and +4 weeks postpartum. Six healthy cows (controls ? CON) and six cows that showed clinical signs of SCM were selected for serum analyses. All serum samples were analyzed for acute phase proteins (APP) haptoglobin (Hp) and serum amyloid A (SAA); proinflammatory cytokines including interleukin 1 (IL-1), IL-6, and tumor necrosis factor (TNF) and serum lactate, BHBA, and NEFA concentration. Data of DMI, milk production, and milk composition were recorded and analyzed.
Results: The results showed that cows with SCM had greater concentrations of SAA, TNF (P?
Conclusions: Results of this study suggest that SCM is preceded by activated innate immunity and altered carbohydrate metabolism in transition dairy cows. Moreover the results support the idea that Hp, lactate, and SAA, at -8 weeks, and TNF and IL-1 at -4 weeks can be used as early indicators to screen cows during dry off for disease state.
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KEYWORD
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Subclinical mastitis, Dairy cows, Transition period, Blood metabolites, Acute phase proteins, Cytokines
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